Network meta-analysis of pharmacological treatments for idiopathic pulmonary fibrosis: evaluating effects on lung function - PubMed
12 hours ago
- #pharmacological treatments
- #idiopathic pulmonary fibrosis
- #network meta-analysis
- Network meta-analysis evaluates pharmacological treatments for idiopathic pulmonary fibrosis (IPF) and their effects on lung function.
- Study includes 121 publications with 16,525 IPF patients across nine countries.
- Nerandomilast found most effective for improving Forced Vital Capacity (FVC).
- N-acetylcysteine (NAC) combined with Roxithromycin (RXM) most effective for Vital Capacity (VC) and FEV1/FVC.
- Ambroxol most effective for improving Total Lung Capacity (TLC).
- Thalidomide most effective for improving Diffusing Capacity of the Lung for Carbon Monoxide (DLCO).
- Findings suggest drugs have specific mechanisms targeting different pulmonary function parameters.
- Future research needed to validate findings and assess long-term effectiveness of new drugs.