The pro-fibrogenic role of SPP1+ macrophages in medical implant fibrosis: mechanisms and therapeutic opportunities - PubMed
2 days ago
- #macrophages
- #fibrosis
- #implants
- SPP1+ macrophages play a key role in fibrosis around medical implants.
- These macrophages originate from CCR2+ monocytes and develop in collagen-rich areas near implants.
- They are recruited via the CCL2-CCR2 axis and remain active in chronic phases.
- SPP1+ macrophages promote fibrosis by activating fibroblasts through osteopontin-CD44 signaling.
- Potential treatments include targeting the CCL2-CCR2 axis, blocking osteopontin-CD44 signaling, and using CRISPR-Cas13 or CAR macrophages.
- Smart biomaterial-based drug delivery systems are also being explored to reduce fibrosis.