ANXA1-mediated mTOR/FABP4 Inhibition Drives Antifibrotic Macrophage Reprogramming in Lupus Nephritis - PubMed
4 days ago
- #lupus nephritis
- #macrophage reprogramming
- #ANXA1
- ANXA1 expression is elevated in lupus nephritis (LN) patients and correlates with fibrosis severity.
- A distinct Anxa1+Spp1+ macrophage subset expands during nephritis and shows a profibrotic signature.
- ANXA1 inhibits mTOR/FABP4 via FPR2/ALX receptor, enhancing fatty acid oxidation and promoting antifibrotic macrophage polarization.
- Treatment with ANXA1-mimetic peptide Ac2-26 reduces fibrosis, renal lipid accumulation, and kidney injury in lupus-prone mice.
- ANXA1 and Anxa1+Spp1+ macrophages are key in renal fibrosis, offering new therapeutic targets for LN.