A Single-Cell Atlas of Pan-Cancer Liver Metastasis Reveals Dynamic Cellular Programs Driving Metastatic Progression and Immune Modulation - PubMed
3 hours ago
- #Immune Modulation
- #Single-Cell Atlas
- #Liver Metastasis
- Single-cell transcriptomic atlas of liver metastases across multiple cancer types analyzed.
- Over 460,000 cells profiled, identifying 121 distinct cellular subtypes.
- Four representative cellular programs (CPs) associated with liver metastasis defined.
- Dynamic transition from immunoactive to immunosuppressive environments observed.
- Key mechanisms of immune evasion and metastatic niche formation elucidated.
- Potential of CP-based stratification to inform therapeutic strategies highlighted.