Usefulness of Molecular Diagnostic Kits for Detecting Helicobacter pylori Infection in Patients Receiving Proton Pump Inhibitors and Potassium-Competitive Acid Blockers - PubMed
3 hours ago
- #antibiotic resistance
- #Helicobacter pylori
- #molecular diagnostics
- Study investigates the Smart Gene H. pylori G molecular diagnostic kit for detecting H. pylori infection and clarithromycin (CAM)-resistance mutations.
- The kit was tested on 253 patients, with 9.1% confirmed H. pylori infections via real-time PCR.
- PPI/P-CAB use did not affect H. pylori DNA levels but lowered UBT values significantly.
- Smart Gene test showed 87.0% sensitivity and 99.6% specificity for H. pylori detection.
- Successful eradication was achieved in 84.6% of treated patients, with CAM-based therapy failing in cases with resistance mutations.
- The Smart Gene test provides rapid results (within 1 hour) and helps avoid unnecessary eradication therapy.