Switching from warfarin to direct oral anticoagulants in frail elderly Asian patients with atrial fibrillation: a Korean nationwide study - PubMed
3 hours ago
- #Atrial Fibrillation
- #Anticoagulants
- #Elderly Care
- Study evaluates switching from warfarin to DOACs in frail elderly Asian AF patients.
- Korean nationwide study using claims data from 2013-2015.
- Patients aged ≥75 with AF, frailty score ≥5, and stable warfarin use included.
- Primary outcome: major bleeding; secondary outcomes: thromboembolic events, net clinical outcome, all-cause death.
- 3349 patients switched to DOACs; 9112 remained on warfarin.
- DOACs associated with higher risks of major bleeding, thromboembolic events, NCO, and all-cause death.
- Subgroup analyses consistently showed higher risks with DOACs compared to warfarin.
- Conclusion: Switching to DOACs may not be advisable for frail elderly Asian AF patients stable on warfarin.