Gut microbial metabolism via hippocampal indole-AhR signaling regulates emotional symptoms - PubMed
5 hours ago
- #gut-brain axis
- #AhR signaling
- #microbial metabolism
- Decreased abundance of Alistipes shahii reduces intestinal indole levels via loss of tryptophanase, impacting microbial tryptophan metabolism.
- Reduced indole diminishes nuclear AhR expression and ventral dentate gyrus granule cell activity in the hippocampus, leading to affective symptoms.
- Interventions like tryptophanase-producing microbiota transplantation, indole supplementation, or AhR agonist diosmin rescue emotional symptoms in IBS model mice.