The gut-heart dialogue: an epigenetic perspective on myocardial infarction - PubMed
4 hours ago
- #epigenetics
- #myocardial infarction
- #gut-heart axis
- Myocardial infarction (MI) is a leading cause of global mortality, with adverse cardiac remodeling and heart failure as persistent challenges.
- The review highlights the 'gut microbiota-epigenetic axis' as a key mechanism linking natural bioactive compounds to cardiac repair after MI.
- Gut microbiota transforms bioactives like dietary fibers and polyphenols into metabolites such as short-chain fatty acids (SCFAs) and urolithin A.
- These microbial metabolites act as epigenetic modulators, remodeling the heart's epigenetic landscape through histone modification and DNA methylation.
- Epigenetic changes regulate gene networks involved in inflammation, energy metabolism, and fibrosis, influencing disease progression.
- Therapeutic strategies include dietary interventions (e.g., high-fiber diets, polyphenol supplementation), probiotics, and postbiotics.
- Integrating gut microbiome metabolism with epigenetic regulation offers novel insights for precision prevention and therapy in MI.