Mitochondrial superoxide sustains a senescence-like phenotype in PARP- inhibited ovarian cancer cells by stabilizing HIF1α - PubMed
3 hours ago
- #Mitochondrial ROS
- #Glycolysis
- #Senescence
- PARP inhibitors induce a senescence-like phenotype in ovarian cancer cells, characterized by cell cycle arrest, β-gal staining, and dysfunctional mitochondria.
- mtROS-driven glycolysis, stabilized by HIF1α, sustains survival in these PARP-inhibited cells.
- Mitochondrial antioxidants, HIF1α inhibition, or glycolysis restriction can block entry into and maintenance of this senescence-like state.
- Combining PARP inhibitors with mitochondrial antioxidants reduces senescence markers, HIF1α activation, and lactate production in tumor xenografts.