Aloe Polysaccharides against 3-Nitropropionic acid-induced Huntington's disease-like symptoms: Role of BDNF/NF-κB/Nrf2 signaling pathways - PubMed
4 hours ago
- #Aloe Polysaccharides
- #Neuroprotection
- #Huntington's Disease
- Aloe Polysaccharides (APs) show neuroprotective effects against 3-Nitropropionic Acid (3-NPA)-induced Huntington's disease (HD)-like symptoms in rats.
- APs treatment improved behavioral performance, restored neurotransmitter balance, and reduced oxidative stress and inflammation.
- The study highlights APs' ability to modulate the BDNF/NF-κB/Nrf2 pathway, enhancing mitochondrial biogenesis and antioxidant defense.
- APs upregulated genes related to mitochondrial biogenesis (Sirt1, PGC-1α, AMPK, UCP1, UCP2) and antioxidant response (HO-1, NQO1).
- Findings suggest APs as a potential natural therapeutic candidate for managing HD by targeting multiple pathological mechanisms.