Type I and III interferon responses restrict infection by tick-borne orthoflaviviruses through IFI6 - PubMed
3 hours ago
- #tick-borne orthoflaviviruses
- #interferon response
- #antiviral immunity
- Tick-borne orthoflaviviruses (TBOVs) pose a growing global health threat, with some causing fatal diseases and increasing case numbers.
- Both type I and type III interferons (IFNs) restrict TBOV infection in human cell lines in a cell type-specific manner, and mouse models confirm IFN signaling is crucial for controlling TBOV replication in vivo.
- A CRISPR/Cas9-KO screen in human cells identified IFI6 as a key antiviral factor for both type I and III IFN responses against TBOVs.
- IFI6 is an ER-resident protein that restricts TBOV replication at a post-entry step, offering new targets for antiviral therapeutics.