Superoxide dismutases maintain niche homeostasis in stem cell populations - PubMed
4 hours ago
- #reactive oxygen species
- #Drosophila
- #stem cell niche
- Reactive oxygen species (ROS) influence cell fate decisions like maintenance and differentiation.
- In Drosophila male germline, Germline Stem Cells (GSCs) and Cyst Stem Cells (CySCs) maintain differential redox thresholds.
- CySCs have a higher redox state compared to GSCs.
- Depletion of Superoxide Dismutases (SODs), especially Sod1, disrupts redox equilibrium, leading to deregulated niche architecture and loss of GSCs.
- ROS-mediated activation of self-renewing signals causes uncontrolled CySC proliferation.
- CySCs with higher ROS serve as non-autonomous redox moderators of GSCs.
- The study highlights the importance of intercellular redox communication in stem cell microenvironments.