Spatially gated oxidative killing: mitoxyperilysis redefines how ROS cause lytic cell death - PubMed
9 hours ago
- #cell death
- #oxidative stress
- #mitochondria
- The landscape of regulated cell death (RCD) has expanded beyond apoptosis-necrosis to include lytic modalities like pyroptosis, necroptosis, and ferroptosis.
- These lytic pathways are defined by distinct biochemical executioners such as caspases, gasdermins, or MLKL, which lead to plasma membrane integrity loss.
- A new lytic cell death modality called mitoxyperilysis has been identified, where plasma membrane rupture is driven by a mitochondria-mediated oxidative attack rather than canonical enzymatic effectors.
- Mitoxyperilysis represents a novel mechanism integrating metabolic stress with innate immune signaling to commit to lytic death.