CTPS1 modulates mitophagy to propel diffuse large B-cell lymphoma via reshaping CEPT1-mediated phospholipid metabolism - PubMed
4 hours ago
- #Mitophagy
- #Phospholipid Metabolism
- #DLBCL
- CTPS1 is a key enzyme in de novo nucleotide synthesis and is linked to poor prognosis in diffuse large B-cell lymphoma (DLBCL).
- High CTPS1 expression in DLBCL activates phospholipid metabolism and mitophagy-related pathways.
- CTPS1 upregulates CEPT1, which reprograms glycerophospholipid metabolism to maintain mitochondrial homeostasis and promote BNIP3-mediated mitophagy.
- The selective CTPS1 inhibitor R80 shows potential in reducing DLBCL cell viability.
- The study highlights CTPS1 as a potential therapeutic target for DLBCL.