Chronic intermittent hypoxia reshapes circadian metabolic architecture in a model of sleep apnea - PubMed
3 hours ago
- #metabolic dysfunction
- #sleep apnea
- #circadian rhythm
- Chronic intermittent hypoxia (IH) in obstructive sleep apnea (OSA) drives metabolic dysfunction.
- 4 weeks of rest phase-restricted IH reprograms hepatic and systemic metabolism in a time-specific manner.
- Metabolic reorganization involves circadian regulation of glucose, lipid, and redox pathways, shifting toward oxygen-sparing processes.
- Hepatic metabolite oscillations and systemic autonomic rhythms adapt to intermittent oxygen availability.
- The cAMP-CREB1 pathway is identified as a driver of circadian transcriptional remodeling in the liver.
- Chronic IH rewires hepatic transcriptional and metabolic programs, revealing a circadian dimension to metabolic consequences of OSA.