Exosomes from macrophages intervened by Jiedu Yangxin decoction mediated endothelial-to-mesenchymal transition to improve myocardial fibrosis after myocardial infarction - PubMed
2 days ago
- #exosomes
- #myocardial fibrosis
- #traditional Chinese medicine
- Jiedu Yangxin decoction (JDYX) improves myocardial fibrosis post-myocardial infarction (MI) by targeting macrophage-derived exosomal miRNAs.
- JDYX attenuates endothelial-to-mesenchymal transition (EndMT), a key driver of fibrosis, by regulating macrophage polarization and exosomal microRNAs.
- Early JDYX intervention (0-7 days post-MI) most effectively preserves cardiac function and reduces fibrosis in mice.
- JDYX increases M2 macrophage markers (Arg-1, IL-10) and reprograms macrophage-derived exosomes to suppress EndMT.
- miR-23b-3p, enriched in JDYX-exosomes, plays a crucial role in the protective effect against EndMT.
- The study combines in vivo (mouse MI model) and in vitro (endothelial cell co-culture) approaches to validate JDYX's mechanism.