Human brain and organoid transcriptomes reveal key receptor tyrosine kinase pathways and genetic signatures in Alzheimer's disease - PubMed
4 hours ago
- #Transcriptomics
- #Alzheimer's Disease
- #Receptor Tyrosine Kinase
- Identified six key disease-associated genes (DAGs) linked to Alzheimer's disease (AD) through RTK pathway analysis: ITGB1, AXL, GFAP, NRG1, CAV1, and RHOA.
- Found that AXL and ITGB1 are significantly upregulated in AD and represent crucial genes in receptor tyrosine kinase (RTK) pathways for the disease.
- Demonstrated high diagnostic potential of the six DAGs, with area under the curve values of 0.825 and 0.884 in two independent brain transcriptome datasets.
- Validated gene expression changes using human brain organoids and primary neurons, supporting the biological relevance of the findings.
- Analysis involved differential gene expression from public datasets, functional enrichment, and protein-protein interaction networks to identify key genetic signatures.