Molecular Insights into the MdtABC Efflux Pump Genes in Clinical Salmonella typhi Isolates from Typhoid Patients - PubMed
2 hours ago
- #Antibiotic resistance
- #Salmonella typhi
- #Efflux pump genes
- Study focuses on efflux pump genes, molecular mutations, and antibiotic susceptibility in Salmonella typhi isolates from typhoid patients.
- Out of 2950 blood samples, 380 bacterial isolates were recovered, with 95 identified as S. typhi (3.22% prevalence).
- High resistance observed to ampicillin (98.94%) and chloramphenicol (93.68%), but none to azithromycin or meropenem.
- Most prevalent efflux pump gene was mdtB (32.63%), followed by mdtC (30.52%) and mdtA (29.47%).
- Multiple mutations identified in efflux pump genes, potentially altering drug binding affinity and increasing resistance.
- Phylogenetic analysis revealed evolutionary relationships with other Salmonella enterica serovars.
- Highlights alarming rise of multidrug resistance in S. typhi and key genetic mutations influencing efflux pump function.