STING Drives Psoriatic Inflammation by Promoting Neutrophil Recruitment and Facilitating NETosis - PubMed
8 hours ago
- #neutrophil activation
- #psoriasis
- #STING pathway
- STING pathway plays a key role in psoriatic inflammation by promoting neutrophil recruitment and NETosis.
- Single-cell RNA-seq and mouse models (STING-/-, PADi4-/-) revealed upregulated STING in psoriatic neutrophils.
- STING knockout in mice reduced disease severity, neutrophil infiltration, and IL-1β release.
- STING regulates neutrophil chemotaxis via IRF3/NF-κB and directly drives NET formation.
- Genetic heterogeneity in STING pathway activation suggests individualized therapeutic responses.
- Targeting STING could inhibit multiple neutrophil-mediated pathogenic processes in psoriasis.