MFF budding from mitochondria regulates melanosome size and maturation - PubMed
4 hours ago
- #MFF
- #melanosome
- #mitochondria
- MFF (mitochondrial fission factor protein) is involved in melanosome fission and maturation.
- MFF is trafficked between mitochondria and melanosomes, localizing at melanosome fission sites.
- Downregulation of MFF leads to enlarged melanosomes, increased melanin accumulation, and altered melanosomal catabolism.
- MFF interacts with ARP2/3 complex regulators, which drive F-actin nucleation for melanosome fission.
- Silencing ARP2/3 subunits mimics the effects of MFF downregulation, increasing melanosome size.
- MFF has an extramitochondrial role in regulating melanosome homeostasis via actin-dependent fission.