0.33 g mitigates muscle atrophy while 0.67 g preserves muscle function and myofiber type composition in mice during spaceflight - PubMed
3 hours ago
- #muscle atrophy
- #spaceflight
- #artificial gravity
- 0.33 g mitigates muscle atrophy in mice during spaceflight.
- 0.67 g preserves muscle function and myofiber type composition in mice during spaceflight.
- The study used the Multiple Artificial-gravity Research System aboard the International Space Station.
- In the soleus muscle, 0.33 g preserved cross-sectional area, while 0.67 g prevented slow-to-fast myofiber transition.
- Functional measures like grip strength and electrical impedance myography showed 0.67 g maintained muscle performance.
- Plasma metabolomics identified 11 metabolites with gravity-dependent changes, suggesting potential biomarkers.
- 0.67 g is identified as a critical threshold for mitigating spaceflight-induced muscle issues.
- Conflict of interest noted for S.B.R. due to involvement with Myolex Inc.