OX40/OX40L modulation: A target for regulating T cells in cutaneous inflammatory disorders - PubMed
3 hours ago
- #T cell regulation
- #dermatology
- #OX40/OX40L
- OX40/OX40L axis is crucial in T cell differentiation and function, making it a promising target for treating T cell-driven cutaneous inflammatory disorders.
- Development of OX40/OX40L agonists and inhibitors shows potential for conditions like atopic dermatitis, alopecia areata, and psoriasis, with trials mainly in atopic dermatitis.
- Drugs such as amlitelimab and rocatinlimab have demonstrated efficacy and increased durability of response, but concerns exist about broad immune suppression with antagonists and disease worsening with agonists.
- Further studies are needed to assess the benefit-risk ratio of these treatments in real-world settings for various dermatological conditions.