High-dose NB-UVB exacerbates vitiligo progression by inducing dermal fibroblast senescence via the p38 MAPK signaling pathway - PubMed
3 hours ago
- #Fibroblast Senescence
- #Vitiligo
- #NB-UVB
- High-dose NB-UVB exacerbates vitiligo progression by inducing dermal fibroblast senescence via the p38 MAPK signaling pathway.
- Dermal fibroblasts play a key role in vitiligo by responding to IFN-γ and secreting chemokines to recruit and activate CD8+ T cells.
- NB-UVB irradiation induces dermal fibroblast senescence and activates both the MAPK and p53 pathways.
- In vitro, high-dose NB-UVB exposure leads to increased senescence and inflammation in vitiligo fibroblasts.
- Low-dose NB-UVB treatment in vitiligo mice reduces CD8+ T cells and increases skin pigmentation.
- High-dose NB-UVB induces a senescent, proinflammatory microenvironment, disrupting skin homeostasis and exacerbating vitiligo progression.