U2AF regulates the translation and localization of nuclear-encoded mitochondrial mRNAs - PubMed
4 hours ago
- #translation regulation
- #mitochondrial mRNA
- #U2AF
- U2AF regulates translation and mitochondrial localization of nuclear-encoded mitochondrial mRNAs.
- The U2AF heterodimer shuttles between nucleus and cytoplasm, influencing splicing and translation.
- An oncogenic U2AF1 mutation disrupts regulation, altering mitochondrial structure and proteome, and rewiring metabolism.
- This U2AF role links to metabolic changes in myelodysplastic syndromes, revealing a non-canonical mitochondrial function.