Laxative use and acute kidney injury risk: Analysis of a Japanese hospital-based database - PubMed
12 hours ago
- #Pharmacology
- #Acute kidney injury
- #Laxative
- Study investigates the association between laxative use and acute kidney injury (AKI) risk.
- Data sourced from a Japanese hospital-based claims database (2014-2022).
- Laxatives studied: lubiprostone, linaclotide (secretory drugs), senna (stimulant), magnesium oxide (nonabsorbed substance).
- AKI incidence rates varied by laxative group but no significant risk difference found.
- Cox regression analysis showed no decreased AKI risk with lubiprostone, senna, or linaclotide compared to magnesium oxide.
- Conclusion: No difference in AKI risk among the studied laxatives.