Programmable macromolecule delivery via engineered trogocytosis - PubMed
10 hours ago
- #trogocytosis
- #cell engineering
- #macromolecule delivery
- The study introduces engineered trogocytosis as a method for programmable macromolecule delivery between cells.
- Key engineering principles include designed receptors, pH-responsive membrane fusion, and inducible cargo localization and release.
- The method is applicable across diverse cell types and operates via a dynamin- and endosome acidification-dependent pathway.
- A delivery system named TRANSFER was developed, offering cell type specificity, tunability, and the ability to deliver large therapeutic proteins and mediate genome editing.
- Trogocytosis is established as a versatile framework for cell-based macromolecular delivery, with potential applications in sensing multiple ligand inputs.