Pathways of mRNA decay in trypanosomes - PubMed
a day ago
- #Trypanosoma brucei
- #gene expression
- #mRNA decay
- mRNA decay is crucial for gene expression in trypanosomes, acting as both a quality control and regulatory mechanism.
- Trypanosoma brucei relies heavily on post-transcriptional mechanisms due to polycistronic transcription and minimal promoter-specific regulation.
- The review covers major nuclear and cytoplasmic mRNA decay pathways in T. brucei, noting conserved and unique features.
- Key processes include roles of exonucleases, deadenylation, decapping, and strategies for mRNA stabilization/destabilization.
- Mechanistic links between cis-regulatory elements, RNA-binding proteins, and decay pathways remain unclear.
- Open questions and new experimental approaches are highlighted to further understand mRNA decay in trypanosomes.