NAD+ controls circadian rhythmicity during cardiac aging - PubMed
7 hours ago
- #cardiac aging
- #circadian rhythm
- #NAD+
- Disruption of the circadian clock and reduced NAD+ levels are hallmarks of aging.
- Aging disrupts diurnal gene expression in the heart.
- NAD+ precursor nicotinamide riboside (NR) supplementation boosts NAD+ levels and reverses cardiac enlargement in aged female mice.
- NR supplementation rescues impaired PER2::luc oscillations in cardiomyocytes with reduced NAD+ levels.
- NR's effect on the cardiac transcriptome partially depends on SIRT1 activity.
- NAD+ plays a crucial role in regulating the cardiac circadian clock during aging.