Therapeutic targeting of neuroimmune mechanisms in neurodegeneration - PubMed
6 days ago
- #neuroimmune
- #microglia
- #neurodegeneration
- Effective treatments for age-related chronic neurodegenerative diseases like Alzheimer's are limited due to incomplete understanding of molecular drivers.
- Human genetic studies and disease pathology analysis highlight the immune system's role in disease progression.
- Research focuses on microglia, CNS-resident innate immune cells, revealing their influence on neurodegeneration and identifying potential therapeutic targets.
- Microglia interact with CNS and peripheral cell populations, shaping disease outcomes and suggesting a complex neuroimmune framework.
- New therapeutic strategies and disease-specific neuroimmune biomarkers are needed to complement existing therapies targeting core pathological features.