Tumor-specific lncRNA IGF1R-AS1 trans-regulates chromatin interactions associated with oncogenic MYC signaling - PubMed
5 hours ago
- #chromatin interactions
- #lncRNA
- #MYC signaling
- LncRNAs are important regulators in human cancers but their mechanisms are not fully understood due to their cell type- and tissue-specific expression.
- Study identifies IGF1R-AS1, a tumor-specific lncRNA associated with super-enhancers, overexpressed in prostate and lung cancers.
- IGF1R-AS1 interacts with chromatin remodeling complexes to facilitate long-range chromatin looping, leading to MYC overexpression and tumorigenicity.
- Findings suggest IGF1R-AS1 plays a key role in MYC-driven malignancies by modulating oncogenic MYC expression through chromatin interactions.