TRF2-RAP1 inhibits homology-directed repair of telomeres by promoting BLM-mediated removal of telomere R-loops - PubMed
4 hours ago
- #homology-directed repair
- #telomere maintenance
- #R-loops
- The telomere RNA TERRA forms R-loops at telomeres, which promote homology-directed repair (HDR).
- TRF2-RAP1 complex recruits BLM helicase to remove these telomere R-loops, inhibiting HDR and preventing abnormal telomere clustering.
- RAD51AP1 and TERRA-dependent R-loops facilitate RAD51-mediated D-loop formation in a length- and sequence-dependent manner.
- BLM deficiency or mutation disrupts R-loop removal, leading to accumulation of R-loops and ultrabright telomeres.
- The study reveals a mechanism where TRF2-RAP1-BLM complex suppresses telomere HDR by clearing R-loops.