Sex-Based Differences in Disease Burden and Phenotype in CADASIL: A Multicenter Study of 368 Korean Patients - PubMed
3 hours ago
- #sex differences
- #Korean population
- #CADASIL
- Study investigates sex-based differences in CADASIL among 368 Korean patients.
- Men showed higher prevalence and earlier onset of ischemic stroke compared to women.
- Male patients had greater lacune burden on brain MRI, while females had higher WMH volume.
- Most frequent pathogenic variant was R544C (40.8%), located at EGFr 13/14 interdomain boundary.
- Findings highlight the need for sex-informed clinical management in CADASIL.