Hypomagnesemia: A Clinical and Nutritional Update - PubMed
4 hours ago
- #Hypomagnesemia
- #Nutrition
- #Magnesium deficiency
- Hypomagnesemia is a prevalent but underrecognized electrolyte disorder with significant clinical and nutritional implications.
- Low serum or dietary magnesium is linked to increased risks of cardiometabolic disorders, neuropsychiatric conditions, osteoporosis, and immune dysregulation.
- Mechanistic studies highlight the roles of TRPM6/7 channels and magnesium transporters in intestinal and renal magnesium handling.
- Modern dietary patterns, food processing, medication use, and gut microbiome alterations contribute to widespread subclinical magnesium deficiency.
- Magnesium supplementation shows modest but clinically relevant benefits in blood pressure, glycemic control, migraine frequency, and depressive symptoms.
- Serum magnesium is an insensitive biomarker, and consensus on optimal diagnostic thresholds and replacement strategies is lacking.
- Management includes dietary modification, supplementation, and addressing underlying causes of deficiency.
- Future research should focus on improved diagnostic tools, personalized dosing, and long-term outcomes of magnesium repletion.