Lipid-dependent accrual of a subset of monocyte-derived macrophages is essential for tissue regeneration - PubMed
12 hours ago
- #liver regeneration
- #macrophages
- #lipid metabolism
- A subset of monocyte-derived macrophages (MDMs), termed 'lipo-inflammatory MDMs' (LIMMs), is essential for tissue regeneration in the liver.
- LIMMs are characterized by high lipid content and an inflammatory response, distinct from other hepatic macrophages like Kupffer cells.
- CD36-dependent induction of LIMMs is crucial for hepatocyte proliferation and liver regeneration.
- CD36-mediated ceramide biosynthesis activates the IRE1α-XBP1 signaling pathway in LIMMs, leading to interleukin-6 production, a key regenerative cytokine.
- Blocking CD36-dependent LIMM induction or disrupting IRE1α activation impairs liver repair.
- Multi-omic analyses (single-cell transcriptomics and lipidomics) reveal significant cellular diversity and heterogeneity among hepatic macrophages.