HPV, Cytology, and Cotest Cervical Cancer Screening and the Risk of Precancer - PubMed
a day ago
- #HPV screening
- #cervical cancer
- #precancer risk
- HPV-negative testing shows lower risk of future precancer compared to normal cytology.
- The study compares long-term risk of cervical precancer based on HPV, cytology, and cotest screening results.
- Participants included women who completed trial exit cotesting, with data analyzed from 2006 to 2012.
- HPV-positive with abnormal cytology had the highest cumulative incidence risk (CIR) of cervical intraepithelial neoplasia grade 2 or higher (43.47%).
- HPV-negative with normal cytology had the lowest CIR (0.37%).
- HPV-negative individuals (regardless of cytology) had similar low risk to those with negative cotests, both lower than normal cytology results.
- The study concludes that primary HPV testing may be more cost-effective than cotesting, with limited additional benefits from cotesting.