Hippocampal Neuronal Ferroptosis Driven by Lipocalin-2 Mediates Comorbid Visceral Pain and Anxiety in Irritable Bowel Syndrome - PubMed
4 hours ago
- #Irritable Bowel Syndrome
- #Ferroptosis
- #Gut-Brain Axis
- Hippocampal Lipocalin-2 (LCN2) drives neuronal ferroptosis in IBS.
- LCN2-mediated ferroptosis links visceral pain and anxiety in IBS.
- Ferroptosis inhibition reverses pain and anxiety-like behaviors in IBS models.
- LCN2 knockdown in hippocampal CA1 alleviates IBS symptoms.
- Study identifies LCN2-ferroptosis axis as a new therapeutic target for IBS.