Multi-Omics Analysis Identified LTB4R as a Peripheral Blood Diagnostic Biomarker for Colorectal Cancer - PubMed
7 hours ago
- #Biomarker
- #Multi-Omics
- #Colorectal Cancer
- LTB4R gene is significantly upregulated in both tumor tissues and peripheral blood of colorectal cancer (CRC) patients.
- LTB4R is primarily expressed in immune cells like macrophages and T cells and shows a negative correlation with M1-type macrophages, suggesting a pro-tumorigenic role by suppressing M1 macrophage activity.
- Simulated knockout of LTB4R affects immune-related pathways, indicating its involvement in immune response and immune receptor activity.
- The study proposes LTB4R as a potential peripheral blood diagnostic biomarker for CRC, aiding in early diagnosis and tumor screening.