Marine sulfated glycan inhibits tau-heparan sulfate interaction and tau cellular uptake - PubMed
4 hours ago
- #Alzheimer's disease
- #marine sulfated glycans
- #tau-heparan sulfate interaction
- Marine sulfated glycans, particularly fucosylated chondroitin sulfates (FucCS), bind tau with high affinity and inhibit tau-heparan sulfate interaction.
- FucCS from holothurian species shows complex binding to tau, distinct from heparin, involving high-affinity and weaker binding sites.
- FucCS inhibits tau cellular uptake in SH-SY5Y cells with an IC50 of 130 μg/mL, suggesting therapeutic potential for Alzheimer's disease.