Dynamic S-Acylation of GSDMA Regulates Pyroptosis - PubMed
3 hours ago
- #S-acylation
- #Pyroptosis
- #GSDMA
- GSDMA is a key gasdermin family member in skin, crucial for pathogen-induced pyroptosis during infection.
- GSDMA undergoes S-acylation at conserved cysteine residues in its N-terminal domain, promoting pyroptosis by facilitating membrane anchoring and oligomerization.
- Recombinant GSDMA and GSDMD proteins can be S-acylated in vitro directly via interaction with palmitoyl-CoA, independent of palmitoyl transferases.
- ABHD17A is identified as a deacylating enzyme regulating the dynamic fatty acylation cycle of GSDMA.
- The study reveals a distinct S-acylation mechanism for GSDMA compared to GSDMD palmitoylation, highlighting its role in regulating pyroptosis.