Insects manipulate host nuclear trafficking and epigenetic regulation to facilitate herbivory - PubMed
3 hours ago
- #Insect herbivory
- #Plant defense
- #Epigenetic regulation
- The article discusses an insect salivary effector named NlAMSP from Nilaparvata lugens that targets host plant cells.
- NlAMSP contains a nuclear localization signal (NLS) and is secreted into rice, where it enters the nucleus via the importin-α/β pathway.
- SUMOylation within the NLS enhances nuclear localization and stability by preventing autophagy.
- In plants, NlAMSP interacts with histone deacetylase OsHDA706, moving it to the nucleus and disrupting its cytoplasmic interaction with JA biosynthesis regulator OsLOX14.
- This reduces OsLOX14 accumulation and suppresses JA-associated defense responses.
- Nuclear OsHDA706 decreases histone acetylation (H4K5ac, H4K8ac), suppressing expression of resistance genes (NLR and WRKY).
- The study reveals how an insect effector manipulates host nuclear trafficking and epigenetic regulation to facilitate herbivory.