Hashimoto's Thyroiditis Beyond Thyroid Hormones: A Systematic Review of Autoimmunity, Inflammation, and Multidimensional Burden - PubMed

4 hours ago

Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease.
Persistent symptoms in HT patients suggest autoimmunity and inflammation affect quality of life (QoL) beyond thyroid hormone levels.
HT patients, often euthyroid or on levothyroxine, report lower QoL, especially in cognitive, affective, and vitality domains.
Elevated anti-thyroid antibodies (anti-TPO, anti-Tg) negatively correlate with QoL, unlike TSH and thyroid hormone levels.
Interventions like total thyroidectomy or therapies reducing antibody levels show improvements in fatigue and QoL.
Some studies found no direct link between antibody levels and symptom severity, indicating methodological variability.
HT impacts QoL through chronic autoimmunity and low-grade inflammation, challenging a purely TSH-centric treatment model.
A patient-centered approach integrating immunological, psychological, and subjective outcomes is recommended.
More longitudinal and interventional trials are needed to establish causal pathways and personalize therapy.

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