Identification of a critical medication trajectory for depression risk in hypertension: A nationwide dual-cohort longitudinal study in china - PubMed
4 hours ago
- #depression
- #hypertension
- #medication-trajectories
- The study examines the relationship between antihypertensive medication patterns and depression risk in Chinese middle-aged and older adults.
- Two cohorts were used: a primary analysis cohort (4,304 participants) and an independent validation cohort (1,625 participants).
- Four medication trajectories were identified, with the transition from non-use to use showing the highest depression risk (39.3% cumulative incidence).
- This trajectory was significantly associated with increased depression risk (HR=1.389 in primary cohort, HR=1.761 in validation cohort).
- The findings suggest a critical behavioral window for monitoring and mental health intervention in hypertension management.