Risk Factors for Early Disease-Related Mortality Among Patients with Localized Pancreatic Cancer Resected After Neoadjuvant Treatment - PubMed
4 hours ago
- #Pancreatic Cancer
- #Early Mortality
- #Neoadjuvant Treatment
- Study focuses on identifying risk factors for early disease-related mortality within 1-year post-surgery in localized pancreatic cancer patients after neoadjuvant treatment (NAT).
- Retrospective analysis of 418 patients who underwent radical resection for pancreatic ductal adenocarcinoma (PDAC) after at least 3-months of NAT.
- Early-death (ED) defined as disease-related mortality within 12-months of surgery, excluding surgery-related mortality.
- Key findings: Radiological tumor size ≥ 25 mm and CA19-9 ≥ 100 U/mL were independently associated with ED.
- Associations confirmed in an external cohort of 473 patients.
- Conclusions: Post-treatment CA19-9 ≥ 100 U/mL and tumor size ≥ 25 mm are warning signs for early-death, important for surgical decision-making and preoperative counseling.