Women and psychosis: a guide to evidence-based, hormone-informed care - PubMed
8 hours ago
- #women's health
- #psychosis
- #hormone-informed care
- Psychosis shows sex differences often overlooked in care, with estrogen providing protective effects.
- Low-estrogen states like perimenstruation, postpartum, and menopause transition increase symptom exacerbation and relapse risk.
- Antipsychotic dosing and response vary by sex and hormonal status: premenopausal women need lower doses, while postmenopausal women have reduced efficacy.
- Antipsychotic-induced hyperprolactinemia can suppress endogenous estrogen, worsening mental and physical health risks.
- Current treatment guidelines are largely sex-neutral, lacking hormone-informed approaches.
- Key recommendations include assessing hormonal status, sex-specific prescribing, and using estrogen-based interventions like hormonal contraception or therapy.