A blueprint for local and distal invasion programs in glioblastoma - PubMed
4 hours ago
- #glioblastoma
- #invasion
- #transcriptomics
- Study combines single-cell RNA sequencing, spatial transcriptomics, and multiplexed imaging to investigate glioblastoma invasion.
- Distal invasion potential glioblastoma models are enriched with oligodendrocyte progenitor-like cells, while local invasion models have mesenchymal-like cells.
- Invasion routes differ: peri-axonal for distal invasion and peri-vascular for local invasion.
- Transcriptional programs associated with invasion potential and the process of invasion are decoupled.
- Findings validated by spatial transcriptomics and multiplexed imaging, describing the spatial niche of invasive cells.
- Provides a blueprint for glioblastoma cell states' invasive potential and associated programs.