Clinicopathological and transcriptomic profiles of 101 patients with diffuse large B-cell lymphoma/high-grade B-cell lymphoma with double-hit MYC and BCL2 or BCL6 and triple hit - PubMed
4 hours ago
- #Molecular Subtypes
- #DLBCL/HGBCL
- #Survival Analysis
- Study analyzes 101 DLBCL/HGBCL cases with MYC, BCL2, BCL6 rearrangements, categorizing them into subtypes: double-hit with BCL2 (DHL-BCL2), triple-hit (TH), and double-hit with BCL6 (DHL-BCL6).
- DLBCL/HGBCL-DH-BCL2 shows higher HGBCL morphology, CD10 positivity, GCB subtype, and molecular high-grade (MHG) features.
- DLBCL/HGBCL-TH is linked to higher LDH levels and worse overall survival compared to other subtypes.
- DLBCL/HGBCL-DH-BCL6 is characterized by higher MUM1 expression, non-GCB subtype, ABC/unclassified cell-of-origin, and lower DHIT/DZ signatures.
- Transcriptomic analysis indicates DLBCL/HGBCL-DH-BCL2 and TH are closely related but distinct from DH-BCL6, with gene set enrichment revealing subtype-specific differences.
- The study recommends analyzing MYC, BCL2, and BCL6 genes in DLBCL/HGBCL diagnosis due to distinct clinicopathological and molecular profiles.