Alcohol consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): understanding the gut-liver crosstalk for clinical translation - PubMed
a day ago
- #steatohepatitis
- #gut-liver axis
- #microbiome
- Alcohol and high-fat, high-cholesterol diet (HFHC) synergistically worsen steatotic liver disease (SLD).
- Disruption of the intestinal barrier leads to LPS leakage, causing TLR4-mediated hepatic inflammation.
- Impaired intrahepatic lipid oxidation, particularly due to insufficient CPT-1 activity, contributes to steatohepatitis.
- Gut microbiota changes in mice resemble dysbiosis in MASLD patients with alcohol consumption.
- Antibiotic-induced microbiota depletion (AIMD) improves pathology, indicating microbiota's causal role.
- Microbiome modulation via fecal microbiota transplant (FMT) shows mild improvements in liver and gut health.
- The gut-liver axis is crucial in SLD progression, offering potential therapeutic targets.
- Promoting abstinence and reducing metabolic burden is recommended for MASLD and MetALD patients.