Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS-STING and Toll-like receptors 3 and 4 - PubMed
5 days ago
- #interferon induction
- #immune response
- #ubiquitination
- Lysine-11 (K11)-linked ubiquitination is crucial for TBK1 activation by PRRs like TLR3, TLR4, and cGAS-STING.
- The E3 ligase ANKIB1 attaches K11-linked ubiquitin chains to components of TLR3 and cGAS-STING signalosomes.
- ANKIB1 facilitates Optineurin recruitment, enabling TBK1 and IRF3 activation, leading to type-I/III IFN induction.
- ANKIB1 deficiency in mice reduces IFN induction via TLR3 and cGAS-STING, affecting protection against HSV-1.
- The study highlights ANKIB1-generated K11-linked ubiquitination's role in immune responses activated by cGAS-STING, TLR3, and TLR4.