Mitochondria orchestrated immune microenvironment and response in health and disease-clinically relevant outlook and recommendations - PubMed
3 hours ago
- #cellular metabolism
- #immunotherapy targets
- #mitochondrial immune regulation
- Mitochondria regulate immune cell functions through metabolic reprogramming, dynamics remodeling, autophagy, and intercellular communication.
- Dysfunctional mitochondrial processes can drive immune microenvironment remodeling in diseases like cardiovascular disorders, autoimmune conditions, tumors, and aging.
- Intercellular mitochondrial transfer and mtDAMPs signaling via extracellular vesicles are key mechanisms in immune regulation.
- Mitochondrial-immune remodeling identifies conserved checkpoints as potential therapeutic targets across various diseases.
- Advances in single-cell sequencing and multi-omics enable predictive medicine approaches and personalized immunotherapy strategies.