BZW1 Drives Immune Evasion in Lung Adenocarcinoma via Ferroptosis Suppression - PubMed
4 hours ago
- #immunotherapy
- #BZW1
- #ferroptosis
- BZW1 promotes immune evasion in lung adenocarcinoma (LUAD) by suppressing ferroptosis.
- Ferroptosis is a form of programmed cell death driven by iron-dependent lipid peroxidation and is crucial for anti-tumor immunity.
- BZW1 inhibits ferroptosis by preventing FTH1 degradation via autophagic degradation of NCOA4.
- BZW1 competitively binds with NCOA4, disrupting the FTH1-NCOA4 interaction and inhibiting ferritinophagy-mediated ferritin degradation.
- Suppression of ferroptosis by BZW1 leads to an immunosuppressive microenvironment by reducing immunogenic cell death and impairing T cell activation.
- Targeting the BZW1-ferroptosis axis may enhance the efficacy of immunotherapy in LUAD.